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Anastomotic urethroplasty is a surgical procedure designed to repair a narrowed segment of the urethra, primarily caused by stricture disease. The procedure aims to restore normal urinary function and alleviate any related symptoms, such as difficulty urinating or urinary retention. During the operation, the affected portion of the urethra is identified and excised, thereby removing the scarred and fibrous tissue that contributes to the stricture. This excision typically involves a section of the urethra that may be surrounded by healthy and well-vascularized tissue, ensuring that the reconstructed urethra receives adequate blood supply post-surgery, which is crucial for the healing process. Following the excision, the two healthy ends of the urethra are brought together and directly stitched or anastomosed to create a continuous passage. The technique can be executed as an open surgical approach or a minimally invasive one, depending on the specifics of the patient's case and the surgeon's preference. This procedure is most commonly performed for anterior urethral strictures, which are found in the penile urethra, but can also be applied to posterior urethral strictures with modifications to the technique. Prior to the surgery, patients undergo diagnostic evaluations, including urethroscopy, imaging studies, and possibly urodynamics, to ascertain the length and location of the stricture and to rule out any underlying conditions contributing to urinary dysfunction. Patients benefit from a multidisciplinary approach, often collaborating with urologists who specialize in reconstructive surgery. Post-operative care is essential to ensure optimal recovery; patients typically have a urinary catheter placed for several days following the procedure to allow the anastomosis to heal without tension. This catheter helps drain urine and minimizes the risk of complications such as stricture recurrence or infection. Patients are usually advised on post-operative activities, pain management, and potential signs of complications such as bleeding or excessive swelling that would necessitate immediate medical attention. The overall success of anastomotic urethroplasty is significantly high, with most patients experiencing a marked improvement in their urinary symptoms and quality of life. However, as with any surgical intervention, risks and complications such as urethral stricture recurrence, fistula formation, and erectile dysfunction can occur and should be discussed thoroughly with the patient before the procedure. Long-term follow-up is recommended to monitor the integrity of the anastomosis and to ensure that any potential complications are managed promptly. Ultimately, anastomotic urethroplasty represents a cornerstone technique in reconstructive urology, offering significant benefits to individuals suffering from urethral strictures and contributing positively to their overall health and well-being.